DPP4 and obesity due to melanocortin 4 receptor deficiency: Moreover, there were some trends toward inverse correlations between DPP4 activity and adiponectin (P = 0.05), an adipokine with insulin sensitizer properties that is inversely related to general obesity and central fat distribution [25] and also between DPP4 activityAUC and adiponectinAUC (P = 0.05) during the postprandial period.