MYC and neoplasm: Most of these cell lines perform already in the un-infected state a highly activated metabolism, in most cases caused by the permanent activation of oncogenes (e.g., Myc in J774 MPs) or the inactivation of tumor suppressors (e.g., p53 in Caco-2, HeLa, U-937, THP-1) (Scheffner et al., 1991; Sugimoto et al., 1992; Berglind et al., 2008).