KSHV-positive cell lines (BCBL-1 and BC-3) and KSHV-negative type cells (BJAB and DG75), renal carcinoma VHL-null cell line 786-O, human osteosarcoma p53-null cell line Saos-2, and human embryonic kidney 293 (HEK293) and U2OS cell lines (Cai et al., 2007). The gene discussed is VHL; the disease is renal carcinoma.