VEGFA and cancer: Currently, a genome-wide association study(GWAS) conducted by O'Mara and Glubb (49) identified 9 new susceptibility loci for endometrial cancer, and one loci is NF1 (17q11.2) which encodes a negative regulator of RAS-mediated signal transduction (48).KDR also known as VEGFR, encodes a receptor of vascular endothelial growth factor and has a pivotal role in promoting cancer angiogenesis (50).