CTCF and neoplasm: And the top 9 highly mutated genes (PTEN, PIK3CA, PIK3R1, CTNNB1, ARID1A, KRAS, CTCF, FGFR2, ARID5B) together with TP53 and FOXA2 had stronger tendency to be tumor driver genes compared to other genes (P < 10−7, Figure 2).