TGFB1 and pancreatic adenocarcinoma: Notably, although TGFβ has long been established as a potent inducer of collagen synthesis and differentiation of stromal cells such as fibroblasts, recent studies have found that TGFβ inhibition in itself can lead to a decrease in pericytes coverage, resulting in enhance tumor vessel permeability in pancreatic adenocarcinoma.20 These findings further highlight the multifunctional and heterogeneous role of TGFβ in tumorigenesis in different tumor models.