Notably, although TGFβ has long been established as a potent inducer of collagen synthesis and differentiation of stromal cells such as fibroblasts, recent studies have found that TGFβ inhibition in itself can lead to a decrease in pericytes coverage, resulting in enhance tumor vessel permeability in pancreatic adenocarcinoma.20 These findings further highlight the multifunctional and heterogeneous role of TGFβ in tumorigenesis in different tumor models. Here, TGFB1 is linked to neoplasm.