IL6 and melanoma: Previous studies implicated that IL‐6 expression correlated with T cell proliferation and function,23 while IL‐2 played a critical role in the activation of immune system by regulating lymphocytes.24 As depicted in Figure 8H, there were no significant alterations between each group with regard to serum IL‐2 and IL‐6 levels, suggesting that IL‐2 and IL‐6 signal transductions were not associated with melanoma progression in this study.