CD4+CD8+ double positive T cells are confirmed to produce elevated levels of TNF‐α in response to melanoma compared with CD8+ T cells suggesting a cytotoxic potential,30 while another study also shows CD4+CD8+ double positive T cells possess an enhanced capacity to secret proinflammatory cytokines including TNF‐α and IFN‐γ. This evidence concerns the gene CD4 and melanoma.