As depicted in Figure5A, topical 20% w/w CAH cream or 20% CDG2/HA cream resulted in a significant increase in TEWL as compared to those of the mice treated with blank cream or 20% 5‐ALA, suggesting CDG2/HA formulation readily impaired the skin integrity (Figure 5A). Here, TGFBI is linked to congenital adrenal hyperplasia.