CHCHD4 and neoplasm: Furthermore, we found that elevated CHCHD4 expression led to significantly increased tumour cell growth in both normoxia (Fig. 2d) and hypoxia (Additional file 4c), while the growth of CHCHD4 (C66A/C68A)-expressing cells was similar to control cells (Fig. 2d and Additional file 4c), indicating that increased expression of CHCHD4 in tumour cells provides a proliferative advantage in both normoxia and hypoxia.