Recently, we found that loss of CHCHD4 in renal carcinoma cells leads to decreased expression of a range of respiratory chain subunits including NDUFS3 (CI), SDHA (complex II, CII), UQCRC2 (complex III, CIII) and COXIV (CIV) [26], indicating that CHCHD4 controls the expression of a broader range of respiratory chain subunits than had previously been considered. This evidence concerns the gene UQCRC2 and renal carcinoma.