In multivariable analysis, AFP, per Log 10 μg/L increase (OR, 1.34; 95% CI 1.06 to 1.69; P = 0.034), clinically significant portal hypertension (CSPH) (OR, 1.75; 95% CI 1.10 to 2.81; P = 0.034), extent of PVTT (OR, 1.81; 95% CI 0.99 to 3.53; P = 0.043) and tumor differentiation III–IV (OR, 3.93; 95% CI 1.56 to 10.18; P = 0.017) were significantly associated with death within 2 years. This evidence concerns the gene AFP and liver disorder.