It appears that IFN participates in endothelial disruption by interruption and uncontrolled activation of complex pathways of complement regulation.53 In a 48-year-old woman with RRMS treated with INFβ-1b, hemolytic-uremic syndrome (HUS) was diagnosed after she presented with signs of hypertension, asthenia, and loss of muscular strength in the legs. The gene discussed is IFNA1; the disease is hemolytic-uremic syndrome.