Although recent evaluations confer a major role for Th17 cell cytokines and transcription factors in MS,   10  T-bet is still necessary for the survival of Th17 cells through regulating the expression of the IL-23 receptor.        11  Furthermore, many studies indicate a boost in TBX21 expression during relapses of patients with Relapsing-Remitting MS (RRMS),   12  suggesting it as a probable biomarker in immune-related diseases.   13. This evidence concerns the gene TBX21 and myeloid sarcoma.