APP and neuroblastoma: Cai et al. [9] using human SH-SY5Y neuroblastoma cells stably transfected with wild-type APPwt695 demonstrated that low (physiological) levels of NO given in the form of sodium nitroprusside can inhibit the amyloidogenic processing of APP, whereas extra-high (pathological) concentrations of NO favor the amyloidogenic pathway of APP processing.