As for rs3747811 (IKBKB), it has not been yet investigated in previous studies for its involvement in the development of obesity-related phenotypes, and was only found to decrease the risk of colorectal cancer combined with rs4648110 (NFKB1) (Seufert et al., 2013). Here, NFKB1 is linked to obesity due to melanocortin 4 receptor deficiency.