SOCS3 and obesity due to melanocortin 4 receptor deficiency: Although, there is no study that has investigated the involvement of rs160978 (NFKB1), this MDR model suggests that the rare allele of rs160978 (NFKB1) may increase the activation of the NF-κB complex, which may contribute to an increased risk of obesity-related phenotypes in the presence of the wild type genotype (i.e., two common alleles) for rs6501199 (SOCS3).