IL-33 potently induces eosinophilia in in vivo murine models (32, 33) and activates eosinophils, the principal effector cells in allergic inflammation, to produce superoxide (34), upregulates the expression of adhesion molecules and enhances eosinophil survival (35), suggesting that it can play an important role in the exacerbation of inflammation in allergic diseases mediated by the activation of eosinophils. The gene discussed is IL33; the disease is Increased total eosinophil count.