Eupatilin (20 ml of 1.5% or 3.0%) improved AD-like symptoms in an oxazolone-induced AD-like mouse model by suppressing the serum levels of IgE, IL-4, and AD-related cytokines including TNFα, IFN-γ, IL-1β, TSLP, IL-25, and IL-33 (122). Here, IGHE is linked to Alzheimer disease.