Suppress both epidermal and dermal thickness, alleviating dermatitis and reducing IL-33 and ST2 positive cell numbers in OVA-induced AD mice Suppress the concentration of specific IgE, IgG, IgG1, and IgG2a antibodies in serum and the expression of IL-33, ST2, IL-1RAcP, IL-4, and IL-13 mRNA in the skin Down-regulate TNF-α and IFN-γ-induced IL-33 mRNA and protein expression in human keratinocyte HaCaT cells. The gene discussed is IGHE; the disease is Alzheimer disease.