In this review, we focus on the recent advances of the underlying intercellular and intracellular mechanisms by which IL-33 can regulate various key immune cells in the allergic inflammatory diseases including allergic asthma and AD, and the future pharmacological strategy and the potential application of traditional Chinese medicines targeting the IL-33/ST2 axis for the treatment of allergic inflammatory diseases. Here, IL1RL1 is linked to allergic asthma.