Production of pro-inflammatory cytokines induced by IL-33 from ST2-expressing structural cells and hematopoietic cells including ILC2s, mast cells, Th2 cells, eosinophils, basophils, dendritic cells, and alternatively activated macrophages (AAM) is crucial to provoke atopic diseases such as allergic asthma and AD (83, 92, 93). This evidence concerns the gene IL33 and allergic asthma.