MAPT and frontotemporal dementia: In parallel, mouse models of tauopathies, in particular the hTauP301S (Allen et al., 2002) and PS19 mice (Yoshiyama et al., 2007), have become popular to study the tau component of the AD pathology (Gotz et al., 2007), although their main limitation resides in the expression of human tau harboring mutations seen in frontotemporal dementia and parkinsonism linked to chromosome 17 and not in AD.