Meanwhile, miRNAs (hsa-mir-99a, hsa-mir-337, and hsa-mir-137) and mRNA (NOSTRIN, TIMP4, GRB14, HOXB9, CELSR3, ADGRD2) were showed to be significant independent factors for poor survival in HNSCC. The gene discussed is ADGRD2; the disease is head and neck squamous cell carcinoma.