Meanwhile, miRNAs (hsa-mir-99a, hsa-mir-337, and hsa-mir-137) and mRNA (NOSTRIN, TIMP4, GRB14, HOXB9, CELSR3, ADGRD2) were showed to be significant independent factors for poor survival in HNSCC. This evidence concerns the gene NOSTRIN and head and neck squamous cell carcinoma.