NCS1 and neuropathy: NCS-1/InsP3R interaction is also considered to mediate neuropathy (Boehmerle et al., 2006, 2007; Blachford et al., 2009), as paclitaxel (taxol), a chemotherapeutic agent used for the treatment of solid cancers, modulates the expression/function of NCS-1, and hence InsP3R1-mediated Ca2+ signaling.