This provides a discrepancy in the interpretation of results based on variants in the IL6R and CRP gene regions: variants in the CRP gene region associated with increased CRP levels were associated with increased risk of depression, whereas variants in the IL6R gene region associated with increased circulating IL-6 levels but decreased IL-6 activity and decreased CRP levels were associated with increased risk of depression. Here, IL6 is linked to depressive symptom measurement.