PLOD1 and alcohol dependence: Future studies are needed to (i) examine the role of the CRFCeA-BNST pathway in females, (ii) determine whether our negative findings with the CRFCeA-SI, CRFCeA-LH/pSTN, and CRFCeA-PBN pathways are attributable to technical limitations, (iii) determine whether these three pathways are involved in other aspects of alcohol dependence that were not examined in the present study, and (iv) determine the effect of the optogenetic inhibition of CRFCeA-BNST, CRFCeA-SI, CRFCeA-LH/pSTN, and CRFCeA-PBN terminals in nondependent animals.