In this study, we further confirmed that LPLUNC1 and PHB1 were significantly downregulated at the mRNA level in NPC tissues, and there was a significantly positive correlation between LPLUNC1 and PHB1 expression in NPC, suggesting that PHB1 was involved in the role of LPLUNC1 in suppression of NPC. Here, BPIFB1 is linked to nasopharyngeal carcinoma.