We found that respective upregulation of LPLUNC1 and PHB1 obviously inhibited activation of the NF-κB pathway, even by LPS stimulation, but inhibition of LPLUNC1 on blockage of the NF-κB pathway was significantly reversed by knockdown of PHB1, and thus LPLUNC1 can inhibit activation of the NF-κB signalling pathway mediated by PHB1, consequently contributing to inhibition of the growth of NPC. The gene discussed is NFKB1; the disease is nasopharyngeal carcinoma.