Western blot analysis also showed that the level of phosphorylated-NF-κB p65 in LPLUNC1 overexpression NPC cells was obviously lower than in control cells in both the absence and presence of LPS, accompanied by upregulation of IκBα expression, while the effect of LPLUNC1 on NF-κB p65 and IκBα was obviously reversed by knockdown of PHB1 (Fig. 7d). This evidence concerns the gene NFKBIA and nasopharyngeal carcinoma.