In the setting of obesity, the decrease in the expression of DNAJB3 has been shown previously by our group to be concomitant with increased expression of IL-6 mRNA, however it was not clear whether a decrease of DNAJB3 was due to increased expression of IL-6 or vice-versa (i.e., cause/effect relationship). This evidence concerns the gene DNAJB3 and obesity due to melanocortin 4 receptor deficiency.