Our analysis found that the NUCKS1 eQTL and a PD meta-GWAS locus are colocalized, suggesting that PD genetic risk influences the striatal expression of NUCKS1. Since transcriptional targets of NUCKS1 were enriched in the Mediumpurple2 network, our finding raises an intriguing hypothesis that genetic variations at the PARK16 locus contribute to the risks of PD at least in part by influencing the expression of NUCKS1, which in turn regulates a striatal gene network sensitive to dopamine and important for PD symptoms. Here, NUCKS1 is linked to Parkinson disease.