CLOCK and Parkinson disease: In addition to mitosis-/cancer-related pathways (mitotic spindle and YAP1 and WWTR1 controlled genes expression), molecular functions highlighted by this analysis included chromatin modification and organization, PPAR-gamma pathway, Notch signaling, circadian clock regulated gene expression, and mRNA processing, suggesting potential molecular processes linking striatal pathology of PD to the emergence of sleep and mood symptoms.