The Mediumpurple2 module appeared to be the most robustly upregulated network across a range of genetic and neurotoxin models of PD, including the LRRK2-R1441G transgenic mice, Pink1 knockout mice (6 and 24 weeks old), SNCA-A53T transgenic mice (6 months old), Pink1−/−/SNCA-A53T double mutant mice (6 weeks old), methamphetamine-treated mice, as well as two MPTP (neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) models. This evidence concerns the gene LRRK2 and Parkinson disease.