The median CCF of del(3p) was the highest among all the somatic events and several other arm-level SCNAs including del(1), amp(5q) and del(14q) also had slightly higher medians of CCFs than the well-known renal cancer driver VHL mutations, suggesting that the acquirement of certain arm-level SCNAs may play initialing roles in the early stage of ccRCC evolution. Here, VHL is linked to nonpapillary renal cell carcinoma.