Of the different potential routes of ccRCC evolution (Fig. 3b), the earliest event del(3p) was followed by three groups of departure points: (i) somatic mutations involving VHL and PBRM1, (ii) del(14q), and (iii) arm-level SCNAs including amp(7), del(1p) and del(6q). Here, PBRM1 is linked to nonpapillary renal cell carcinoma.