Arm-level SCNAs including del(3p), amp(5q), amp(7q), del(9p), amp(12p) and del(14q) were found to affect 45–85% of ccRCC patients and several driver genes including VHL, PBRM1, SETD2 and BAP1 were observed to be mutated in 10–50% of patients. The gene discussed is BAP1; the disease is nonpapillary renal cell carcinoma.