MUC16 and nonpapillary renal cell carcinoma: For instance, mutations in LRP2 (P = 0.037, FDR = 0.1) showed a tendency to be clonal while mutations in MUC16 (P < 0.0001, FDR < 0.0001), PCLO (P = 0.0003, FDR = 0.009) and ABCA13 (P = 0.001, FDR = 0.02) tended to be subclonal, highlighting their potential roles in either the genesis or progression of ccRCC.