CD8A and nonpapillary renal cell carcinoma: For the relatively short-lived ccRCC patients (clusters A and C) with a high burden of arm-level SCNAs, our data showed that their immunosuppressive tumor microenvironment had a low level of infiltrating CD8+ T cells and decreased activities of APM but were infiltrated with high levels of immunosuppressive cells such as Tregs and Th2 cells.