LEF1 and hydrops fetalis: While Wnt signaling favors HF over SG fate, an N‐terminally truncated form of Lef1 (ΔNLef1), unable to bind β‐catenin, converts HF into keratinized epidermal cysts with ectopic sebocytes (Merrill et al, 2001; Niemann et al, 2002; Donati et al, 2017).