APC and colonic neoplasm: To explore whether bazedoxifene could also curb Apc‐dependent colon cancer development, we exploited Cdx2CreERT2; Apcflox mice, which develop tumors within 2 weeks following tamoxifen‐dependent bi‐allelic inactivation of the Apc gene in the epithelium of the colon and cecum (Hinoi et al, 2007; Fig 5A).