To rule out that bazedoxifene directly interferes with canonical WNT signaling in tumors of Lgr5CreERT2; Apcflox mice, we used immunohistochemistry to detect transcriptionally active surrogates of canonical WNT signaling (nuclear β‐catenin) and gp130 signaling (pSTAT3) in tumor epithelium from mice in the bazedoxifene‐ and the vehicle‐treated cohorts. This evidence concerns the gene IL6ST and neoplasm.