Strikingly, in sporadic colon cancer models based on aberrant activation of the β‐catenin/canonical WNT pathway, bazedoxifene treatment also reduces tumor burden in mice following conditional ablation of the Apc suppressor gene using the Lgr5CreERT2‐ or Cdx2CreERT2‐driver alleles. This evidence concerns the gene APC and malignant colon neoplasm.