Akin to our observations that inhibition of gp130 signaling at the level of ligand binding, engagement of the gp130‐receptor‐associated JAK kinases or ultimately activation of the STAT3 signal transducer suppresses tumor formation in gp130Y757F, Lgr5CreERT2; Apcflox and Cdx2CreERT2; Apcflox mice; bazedoxifene treatment replicated these effects. The gene discussed is IL6ST; the disease is neoplasm.