Akin to our observations with the IL11Rα receptor antagonist IL11‐Mutein (Putoczki et al, 2013), we find that bazedoxifene restricts the growth of intestinal tumors by suppressing IL11‐mediated signaling rather than by interfering with excessive canonical WNT signaling that arises from bi‐allelic inactivation of the Apc tumor suppressor gene. Here, IL11 is linked to intestinal neoplasm.