Furthermore, expression of mRNA transcripts for the bona fide STAT3‐target genes Socs3, Icam1, and Reg3a, which are both induced by IL11 in gastric tumors (Putoczki et al, 2013), were significantly decreased in tumors from bazedoxifene‐treated animals (Fig 4G). This evidence concerns the gene SOCS3 and gastric neoplasm.