We identified four new Wilms tumour predisposition genes, TRIM28, FBXW7, KDM3B, and NYNRIN. We showed that FBXW7 and KDM3B are pleiotropic cancer predisposition genes, and that KDM3B and NYNRIN might also cause non-malignant phenotypes, particularly intellectual disability. The gene discussed is FBXW7; the disease is cancer.