Our analyses found three autosomal dominant Wilms tumour predisposition genes—TRIM28, FBXW7, and KDM3B—and one autosomal recessive Wilms tumour predisposition gene, NYNRIN. Constitutional TRIM28 mutations join constitutional WT1 and REST mutations as a relatively common contributor to Wilms tumour predisposition, accounting for about 8% of familial Wilms tumour and about 2% of unselected Wilms tumour.2, 4 We found a strong association between TRIM28 mutations and epithelial Wilms tumour, with most individuals with a TRIM28 mutation having Wilms tumour of predominantly epithelial histology. This evidence concerns the gene WT1 and Wilms tumor.