KDM3B and Wilms tumor: This review led us to the identification of two de-novo KDM3B mutations, a non-synonymous mutation in a child with Wilms tumour and a hyperpigmented lesion on her buttock (ID_7225) and a truncating mutation in a child with hepatoblastoma, hyperpigmentation and hypopigmentation, autism, and intellectual disability (ID_2086; figure 2, table, appendix).