HPSE2 and Ochoa syndrome: Considering the UFS pathology, Lrig2 and heparanase 2 also may be implicated peripherally in the facial nerve biology because persons with UFS have a characteristic grimace upon smiling.5, 6 It had been hypothesized that a lesion affecting the pontine micturition center and the facial nerve nuclei, which control urination and facial expression, respectively, could account for the disparate phenotypes observed in the disease.5