HHLA2 and neoplasm: In multivariate analysis, tumor multiplicity (P = 0.001, hazard ratio [HR] = 2.167, 95%CI 1.375–3.416), MVI (P = 0.007, HR = 1.847, 95%CI 1.179–2.892), LN metastasis (P = 0.001, HR = 2.711 95%CI 1.534–4.791) and high HHLA2 expression (P = 0.025, HR = 1.593, 95%CI 1.059–2.396) continued to be prognostic indicators for OS.