To compare tissue oxygenation and T cell dynamics in healthy BM to that in BM with acute lymphoblastic leukemia (ALL), we infused the immune competent CD2-DsRed/CD11c-YFP dual fluorescent mice with syngeneic cyan-fluorescent leukemia cells transformed by the BCR-Abl fusion protein expression. The gene discussed is CD2; the disease is acute lymphoblastic leukemia.