Similarly, associations of lectin pathway protein concentrations or polymorphisms with SSc organ involvement (including pulmonary hypertension, radiographic interstitial lung disease, and pericardial effusion) and its surrogate measurements (including esophageal symptoms, pulmonary artery pressure, diffusion capacity, FVC, left ventricular ejection fraction, and proteinuria), or the presence of antinuclear autoantibodies (ANA) in general and the presence of SSc-specific autoantibodies in particular were absent (data not shown). The gene discussed is BTG3; the disease is pulmonary hypertension.