KIT and gastrointestinal stromal tumor: Selective tyrosine kinase inhibitors have shown promise in treating cancers driven by activated tyrosine kinases such as EGF receptor (EGFR) in non-small cell lung cancer (NSCLC), Bcr-Abl in chronic myelogenous leukemia (CML), and c-Kit in gastrointestinal stromal tumors (GIST) [1].