SERPING1 and hyperinsulinemic hypoglycemia, familial, 4: Hereditary angioedema with C1-inhibitor (C1-INH) deficiency (C1-INH-HAE) is a rare autosomal dominant disorder (estimated prevalence: 1:150,000 to 1:10,000) [1] characterized by the decreased of C1 inhibitor (C1-INH) activity.