Dividing the measured parameters regarding attack location we found elevated fetuin-A levels only during subcutaneous attacks compared to symptom-free period: 295 (260–325) μg/ml vs. 254 (200–273) μg/ml, p = 0.033; median (25–75 percentile) (n = 12), whereas during submucosal attacks (abdominal plus upper airways localization) fetuin-A levels the difference between “during HAE attacks” and “symptom-free” samples was not statistically significant: 286 (262–320) ug/ml vs. 265 (241–297) ug/ml, n = 12, p = 0.308. This evidence concerns the gene AHSG and hereditary angioedema.