However, MCT-1 knockdown (shMCT-1#3) greatly reduced the tumor development of aggressive IV2–3 cells (1 × 106) after inoculation for 30 days (Fig. 3b), and the greatest difference in shMCT-1 tumor burdens showed a 28.3-fold reduction relative to scramble groups. The gene discussed is MCTS1; the disease is neoplasm.