Looking at more specific clusters, the number of central memory Th1 lymphocytes (CD3+CD4+CD45RO+CCR7+T-bet+) and central memory Tregs (CD3+CD4+CD45RO+CCR7+CD127loCD25+FoxP3+) were greater in the CRPS group (U = 44, P < 0.05 and t25 = 2.208, P < 0.05 respectively; Fig. 3b). The gene discussed is CD4; the disease is complex regional pain syndrome.