CD1C and complex regional pain syndrome: Unsupervised clustering using FlowSOM confirmed that there were significantly fewer CD1c+ mDCs (HLA-DR+CD14−CD11c+CD1c+CD141−) in CRPS (U = 34, P < 0.01), whilst the other two major dendritic cell populations, CD141+ mDCs and pDCs, were unchanged (Fig. 5a).