CD8A and complex regional pain syndrome: We probed the relationship of intracellular signalling in different cell types in individuals in the CRPS group and found that pp38 expression in CD1c+ mDC positively correlated with pSTAT1 expression in central memory CD8+ T lymphocytes (F1,12 = 8.52, r2 = 0.42, P < 0.05, Fig. 6a), and with pp65 expression in central memory Th1 lymphocytes (F1,12 = 4.98, r2 = 0.29; Fig. 6b).