Finally, we observed a significant improvement in CRP-Hs in AP group compared with PL (from 1.85 ± 2.34 to 1.25 ± 1.54 mg/L vs from 1.35 ± 1.01 to 1.58 ± 1.83 mg/L, P < 0.05) (Fig. 3). This evidence concerns the gene CRP and alkaline phosphatase measurement.