Moreover, individual components of the SCF complex, including Cullin1, S-phase kinase associated protein 2 (Skp2), copper metabolism domain containing 1 (Commd1), and cyclin-dependent kinases regulatory subunit 1(Cks1b) have been linked to Bortezomib resistance in multiple myeloma [20]. This evidence concerns the gene COMMD1 and plasma cell myeloma.