Hyperlipidemia is a common genetic disorder inherit by genetic mutations mostly in LDLR, apoB-100, or proprotein convertase subtilisin kexin type 9 (PCSK9) loci which can result in xanthoma, atherosclerosis, coronary atherosclerotic heart disease (CAD), and other cardiovascular diseases [12]. The gene discussed is PCSK9; the disease is hyperlipidemia.