Simultaneously, western blotting results showed that plasma apoB (apoB 100 and apoB 48 included) and apoE (except the 5♀ and 6♂ with apoE proteins were deleted because of the injection of sgRNA6) increased while the apoAI decreased in founder rabbits (Fig. 3b), which verified the previous analysis on the formation of hyperlipidemia. This evidence concerns the gene APOB and hyperlipidemia.