To block signaling from all Shh sources pharmacologic Smo antagonists for HPI were used (sonidegib; vismodegib; XL 139; and HhAntag) and there was a reported minor decrease in TB size in CV after prolonged vismodegib treatment [8], a robust loss of TB cells in FP [3,4], or a rapid elimination of all TB, including those in the soft palate [5,6,7]. Here, SHH is linked to tuberculosis.