The reactivation of PAX1 by curcumin was observed in HeLa (the first immortal cell line cultured by scientists), SiHa (grade II, human cervical tumor cell), and it has been suggested that the reactivation of PAX1 by curcumin may be attributed to its effect on histone deacetylase primarily caused through the downregulation of UHRF1, which may regulate both DNA methylation as well as histone acetylation [58]. The gene discussed is PAX1; the disease is uterine cervix neoplasm.