NFKB1 and neoplasm: Those observations were combined with the evidence that curcumin can prevent degradation of the nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor alpha (I κB α), an inhibitor of the pro-oncogenic NF-κB protein, and can also inhibit nuclear translocation of the NF-κB /p65 subunit, as well as the expression of the oncogenic Notch 1, and thus lead to the abrogation of cellular proliferation and tumor development [59].