ESR1 and breast cancer: Moreover, it has been reported that combinatorial treatment with RVT and pterostilbene can cause the reactivation of ERα expression in ERα-negative MDA-MB-157 breast cancer cells, which is associated with an enrichment of acetyl-H3, acetyl-H3lysine9 (H3K9), and acetyl-H4 active chromatin markers in the ERα promoter region [57].