STIM1 and pancreatic adenocarcinoma: In pancreatic adenocarcinoma, both Stim1 and Orai1 mediate SOCE and have a pro-survival anti-apoptotic role, as Orai1 and/or Stim1 silencing by siRNA enhance 5-Fluoro-Uracile (5-FU) and gemcitabine induced apoptosis [30].