KCNN4 and colorectal cancer: Using cisplatin-resistant colorectal cancer cell, Pillozzi et al. showed that the combined activation of KCa3.1 and inhibition of Kv11.1 by riluzole reduced the level of p-Akt and p-ERK and increased caspase-3, demonstrating a synergic effect with cisplatin to overcome the resistance to this chemotherapeutic agent [109].