ARF1 and head and neck squamous cell carcinoma: We further provided evidence that EGF induces HNSCC cell invasion through the EGFR-Arf1 signaling complex and interrupting it using Exo2 or histone deacetylase inhibitor TSA deters the progression of HNSCC, providing a rational basis for Arf1-targeted anti-HNSCC therapy [45].