RHEB and diabetes mellitus: The Ras subfamily includes 36 different members divided into seven subgroups: Ras proteins, Ras-related proteins (RRAS), Ras-like proteins (Ral), Ras-proximal proteins (Rap), Ras-related associated with diabetes (Rad) and Gem-related proteins (GRE), Ras homolog enriched in brain (Rheb), and Ras-like in all tissues proteins (Rit) [7,15].