On the other hand, the aberrant expression of several small GTPases of this family, such as Rac, Cdc42 and RhoA, in carcinogenic cells enhances cancer promotion and progression by facilitating cell cycle progression and mitosis, disrupting tight cellular junctions that prevent cell mobility and inducing epithelial to mesenchymal transition (EMT) to enhance the formation of secondary tumors [21,22]. Here, CDC42 is linked to cancer.