Combination of cryo-electron microscopy (cryo-EM), NMR, and computational analysis provided reliable high-resolution models of tau interacting with microtubules (MTs) [41,42,43], actin filaments [10], and forming filaments in brains of patients suffering from the Alzheimer’s disease [24,44]. This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.