Although the role of primary cilia in regulating the Wnt pathway is controversial, as demonstrated by some studies in mice and zebrafish in which the impairment of ciliary genes (i.e., Ift88, Ift72, Dync2h1 and Kif3a) had no effect in Wnt responsiveness or Axin2 expression [125,126], in cancer, it seems that cilium disassembly acts as a tumor promoter by enhancing Wnt activity and dysregulating cell proliferation and differentiation. This evidence concerns the gene KIF3A and neoplasm.