As expected, the same methylation pattern of PFKFB2, CXXC5 (tumor hypomethylation in relation to NT and BTL), and ATPV6V0C (tumor hypermethylation in comparison with NT and BTL) described in the microarray analysis and in the TCGA cross-study validation [20] was confirmed. The gene discussed is CXXC5; the disease is neoplasm.