At the germline level, the association between 39 SNPs at telomere-related loci, including TERT, TRF1, TRF2, TNKS2, POT1, TERT-CLPTM1L and the risk of skin cancer was investigated in a nested case-control study including 285 Caucasian cSCC patients. The gene discussed is TERT; the disease is skin neoplasm.