CXCL8 and rheumatoid arthritis: IL-6 enhances production of chemokines such as monocyte chemotactic protein-1 and IL-8 from endothelial cells, mononuclear cells, and fibroblast-like synoviocytes; it also induces adhesion molecules such as ICAM-1 in endothelial cells and induces increased adhesion of monocytes to endothelial cells in RA [75,76].