SOCS6 associates with and inhibits the insulin receptor and is related to cytokine-mediated insulin resistance in SOCS6-overexpressing transgenic mice, while human SOCS7 interacts with STAT5 or STAT3, to prevent nuclear translocation and to attenuate prolactin, growth hormone, and leptin signaling [10,11]. This evidence concerns the gene SOCS6 and Insulin resistance.