Following single and combined treatment with 20 μM C2-ceramide and 10 μM CQ for 24 h, LAMP2 and LC3 I/II were over-expressed; LAMP2 expression was upregulated 2- to 4-fold in NSCLC cells following single treatment with 20 μM C2-ceramide or 10 μM CQ for 24 h. This evidence concerns the gene LAMP2 and non-small cell lung carcinoma.