BRAF and melanoma: Based on the pattern of the most prevalent mutations, four different genetic melanoma subtypes were delineated: (i) BRAF mutant melanomas (~50% of melanomas), (ii) RAS (N,H,K) mutant melanomas (~25% of melanomas), (iii) NF1 mutant melanomas (~15% of melanomas), and (iv) BRAF/NRAR/NF1-(triple) wild-type melanomas (~10% of melanomas) [32].