APOE and cardiovascular disorder: Experiments with knock-out mice have proven that failed expression of APOE leads to a shortened lifespan due to the emergence of typically age-related phenotypes like an altered lipoprotein profile (the forefront of atherosclerosis and cardiovascular disease), neurological disorders, type II diabetes, deficits in immune response, and elevated markers of oxidative stress [69,70,71,72,73,74,75].