Previous studies, in humans and in mice, point in the direction that some of the cognitive deficits of the old are due, among other causes, to the decreased levels or activity of insulin and IGF‐1 receptors and to a reduction in the signaling pathway by PI3K/Akt (Deak & Sonntag, 2012; Zaia & Piantanelli, 2000). This evidence concerns the gene AKT1 and Cognitive impairment.