We hypothesize that early VSMC dysfunction precedes and possibly can trigger endothelial dysfunction associated with the development of atherosclerosis in HGPS consistent with our recent studies showing that VSMC‐specific progerin expression is sufficient to aggravate atherosclerosis and to cause atherosclerosis‐related premature death in apolipoprotein E‐null mice (Hamczyk, Villa‐Bellosta et al., 2018). The gene discussed is LMNA; the disease is atherosclerosis.