LMNA and lipodystrophy: The present study aims to investigate the mechanisms underlying vessel stiffness in HGPS by analyzing vascular structure and mechanics in mutant LmnaG609G/G609G mice, which express progerin ubiquitously and recapitulate the main clinical manifestations of human HGPS (reduced lifespan, lipodystrophy, and bone and cardiovascular abnormalities; Hamczyk, Villa‐Bellosta et al., 2018; Osorio et al., 2011; Villa‐Bellosta et al., 2013).