LMNA and left ventricular hypertrophy: However, ECs appear to be critical effector cells of other progerin‐induced cardiovascular alterations, since transgenic mice overexpressing progerin only in ECs develop perivascular fibrosis in coronary arteries and interstitial myocardial fibrosis, advance to left ventricular hypertrophy associated with diastolic dysfunction, and die prematurely (Osmanagic‐Myers et al., 2018).